Qaabkee ugu wanagsan?
— Tijaabooyin lagu ogaanayo Caabuqa SARS-CoV-2
Kiisaska la xaqiijiyey ee COVID-19, la soo sheegay calaamadaha caafimaad ee caadiga ah waxaa ka mid ah qandho, qufac, myalgia ama daal.Hase yeeshee calaamadahani maaha astaamo u gaar ah COVID-19 sababtoo ah calaamadahani waxay la mid yihiin kuwa kale ee uu fayrasku qaado sida hargabka.Waqtigan xaadirka ah, fayraska nucleic acid Real-Time PCR (rt-PCR), sawir-qaadista CT-ga iyo qaar ka mid ah cabbirrada dhiig-baxa ayaa ah aaladaha aasaasiga ah ee ogaanshaha bukaan-socodka ee caabuqa.Xirmooyinka shaybaadhka badan ayaa la sameeyay oo loo adeegsaday tijaabinta muunadaha bukaanka ee COVID-19 ee Shiinaha CDC1, US CDC2iyo shirkado kale oo gaar loo leeyahay.Tijaabada kahortaga IgG/IgM, oo ah habka tijaabada seerological, ayaa sidoo kale lagu daray si loo ogaado nooca cusboonaysiinta Shiinaha ee ogaanshaha iyo tilmaamaha daaweynta cudurka cusub ee coronavirus (COVID-19), kaas oo la soo saaray 3-dii, Maarso.1.Tijaabada fayraska nucleic acid rt-PCR wali waa habka ogaanshaha caadiga ah ee hadda jira ee ogaanshaha COVID-19.
Talaabo Xoogan®Novel Coronavlrus (SARS-COV-2) Qalabka PCR-waqtiga-dhabta ah ee Multiplex (ogaanshaha saddexda hidde-side)
Haddana xirmooyinkan waqtiga-dhabta ah ee baaritaanka PCR, ee raadinaya walxaha hidde-sidaha ee fayraska, tusaale ahaan sanka, afka, ama dabada, waxay la kulmaan xaddidaadyo badan:
1) Tijaabooyinku waxay leeyihiin waqtiyo badan oo soo celin ah waxayna ku adag yihiin hawlgalka;Guud ahaan waxay qaataan celcelis ahaan 2 ilaa 3 saacadood si ay u soo saaraan natiijooyin.
2) Tijaabada PCR-ga waxay u baahan yihiin shaybaaro shahaado leh, qalab qaali ah iyo farsamoyaqaano tababaran si ay u shaqeeyaan.
3) Waxaa jira tiro diidmo been ah oo rt-PCR ah ee COVID-19.Waxaa laga yaabaa in ay sabab u tahay hoos u dhac ku yimid culeyska fayraska SARS-CoV-2 ee muunada neef-mareenka sare (Novel coronavirus inta badan wuxuu ku dhacaa mareenka neef-mareenka hoose, sida alveoli sambabada) baaritaankuna ma aqoonsan karo dadka uu soo maray caabuqa, bogsaday, iyo waxay ka nadiifiyeen fayraska jirkooda.
Cilmi-baaris uu sameeyay Lirong Zou et al4Waxa la ogaaday in culaysyo badan oo fayras ah la arkay wax yar ka dib markii calaamaduhu bilaabmeen, iyada oo culaysyo fayras ah oo sarreeya laga helay sanka marka loo eego dhuunta iyo qaabka daadinta fayraska nucleic acid ee bukaannada uu ku dhacay SARS-CoV-2 waxay u egtahay kuwa bukaanka qaba hargabka.4oo u muuqda mid ka duwan kan lagu arko bukaannada qaba SARS-CoV-2.
Yang Pan iyo al5shaybaarro taxane ah oo laga qaaday laba bukaan oo ku sugan magaalada Beijing ayaa lagu ogaaday in culeysyada fayraska ee cunaha iyo xaakada ay kor u dhaafeen 5-6 maalmood ka dib markii ay calaamaduhu bilaabmeen. shaybaarka suufka dhuunta.Ma jiro RNA fayrus ah oo laga helay kaadida ama saxarada labadan bukaan.
Tijaabada PCR waxay keentaa uun natiijo togan marka fayrasku weli jiro.Tijaabooyinku ma aqoonsan karaan dadka cudurku soo maray, ka bogsaday, oo fayraska ka sifeeyay jidhkooda.Dhab ahaantii, kaliya 30% -50% ayaa u wanaagsan PCR bukaanada qaba cudurka sambabada ee coronavirus-ka cusub.Bukaanno badan oo novel coronavirus oof-wareen ah lama ogaan karo sababtoo ah baaritaanka aashitada nukliyeerka xun, sidaa darteed ma heli karaan daawaynta u dhiganta wakhtiga.Laga soo bilaabo daabacaadda koowaad ilaa daabacaadda lixaad ee tilmaamaha, ku tiirsanaanta kaliya ee ku saleysan ogaanshaha natiijooyinka baaritaanka aashitada nukliyeerka, taas oo dhibaato weyn u keentay dhakhaatiirta. Isbitaalka, waa dhintay.Intii uu noolaa, waxa uu sameeyay saddex tijaabo oo nucleic acid ah oo ah xaalad qandho iyo qufac, iyo markii ugu dambeysay ee uu helay natiijooyin togan PCR.
Ka dib markii ay ka doodeen khabiiro, waxaa la go'aamiyay in la kordhiyo hababka baaritaanka serum sida calaamad cusub oo ogaanshaha.In kasta oo tijaabooyinka ka hortagga jirka, oo sidoo kale loo yaqaanno shaybaarrada serological, kuwaas oo xaqiijin kara in qof uu cudurka qaaday xitaa ka dib marka habka difaaca jirkooda uu nadiifiyo fayraska sababa COVID-19.
StrongStep® SARS-COV-2 IgG/IgM Baaritaanka Degdegga ah ee Kahortagga Jirka
Tijaabada ka hortagga IgG/IgM waxay kaa caawin doontaa in lagu raadiyo qaab dad badan ku saleysan oo cudurka qaaday, sababtoo ah kiisas badan ayaa u muuqda inay ka faafeen bukaannada asymptomatic-ka ah oo aan si fudud loo aqoonsan karin.Lammaane ku nool Singapore, ninka ayaa laga helay PCR, natiijadii baaritaanka PCR ee xaaskiisa ayaa ahayd diidmo, laakiin natiijada baaritaanka kahortaga jirka ayaa muujisay inay leedahay unugyada difaaca jirka, sidoo kale ninkeeda.
Baaritaannada serological waxay u baahan yihiin in si taxadar leh loo ansixiyo si loo hubiyo inay uga falcelinayaan si la isku halleyn karo, laakiin kaliya unugyada difaaca jirka ee ka hortagga fayraska cusub.Mid ka mid ah walaac ayaa ahaa in isku ekaanshaha u dhexeeya fayrasyada sababa xanuunka daran ee neef-mareenka iyo COVID-19 ay u horseedi karto falcelin-isdhaafsi.IgG-IgM waxaa sameeyay Xue Feng wang6waxaa loo tixgeliyey in loo isticmaali karo baarista-daryeelka (POCT), maadaama lagu samayn karo meel u dhow sariirta oo leh dhiig faraha.Qalabkani waxa uu leeyahay dareenka 88.66% iyo gaar ahaan 90.63%.Si kastaba ha ahaatee, weli waxaa jiray natiijooyin xun oo togan iyo been abuur ah.
Nooca Shiinaha ee la cusboonaysiiyay ee tilmaamaha ogaanshaha iyo daawaynta ee cudurka cusub ee coronavirus (COVID-19)1Kiisaska la xaqiijiyay waxaa lagu qeexay kiisas la tuhunsan yahay oo buuxiyey mid ka mid ah shuruudahan soo socda:
(1) Shaybaarada marinka neefsiga, muunadaha dhiiga ama saxarada ayaa laga helay SARS-CoV-2 nucleic acid iyadoo la isticmaalayo rt-PCR;
(2) Kala-soocidda hidde-sideyaasha fayraska ee marinnada neef-mareenka, shaybaarrada dhiigga ama saxarada ayaa aad isugu mid ah SARS-CoV-2 ee la yaqaan;
(3) Serum novel coronavirus gaar ah IgM antibody iyo IgG antibody ayaa togan;
(4) Serum novel coronavirus-specific IgG antibody is beddelay taban una beddelay togan ama coronavirus-gaar ah IgG antibody inta lagu jiro xilliga soo kabashada ayaa 4 jeer ka sarreysa inta lagu jiro muddada degdega ah.
ogaanshaha iyo daawaynta COVID-19
| Tilmaamaha | La daabacay | Shuruudaha ogaanshaha ee la xaqiijiyay |
| Nooca 7aad | 3-Mar-2020 | ❶ PCR ❷ NGS ❸ IgM+IgG |
| Nooca 6aad | 18 Febraayo 2020 | ❶ PCR ❷ NGS |
Tixraac
1. Tilmaamaha ogaanshaha iyo daawaynta novel coronavirus pneumonia (nooca tijaabada 7, Komishanka Caafimaadka Qaranka ee Jamhuuriyadda Dadka Shiinaha, oo la soo saaray 3.Mar.2020)
http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml
2. Isticmaalka Cilmi Baadhista Hab-maamuuska RT-PCR ee wakhtiga-dhabta ah oo kaliya si loo aqoonsado 2019-nCoV
https://www.cdc.gov/coronavirus/2019-ncov/lab/rt-pcr-detection-instructions.html
3. Singapore waxay sheeganeysaa isticmaalkii ugu horreeyay ee tijaabada kahortagga jirka si loola socdo caabuqyada coronavirus
https://www.sciencemag.org/news/2020/02/singapore-claims-first-use-antibody-test-track-coronavirus-infections
4.SARS-CoV-2 Culayska Fayraska ee Qaababka Sare ee Neefsashada ee Bukaan-jiifka Feebarwari 19,2020 DOI: 10.1056/NEJMc2001737
5. Culayska fayraska ee SARS-CoV-2 ee muunado caafimaad Lancet Infect Dis 2020 La daabacay on February 24, 2020 (https://doi.org/10.1016/S1473-3099(20)30113-4)
6. Koriinka iyo Codsiga Kiliinikada ee Imtixaanka Isku-dhafka IgM-IgG ee Kahortagga Kahortagga ee SARS-CoV-2
ogaanshaha caabuqa XueFeng Wang ORCID iD: 0000-0001-8854-275X
Waqtiga boostada: Mar-17-2020
